"Gender-Affirming Psychiatric Care is dedicated to providing affirming, intersectional, and evidence-informed psychiatric care for transgender, non-binary, and/or gender-expansive (TNG) people. The handbook discusses epidemiology, the neuroscience of gender, and psychopharmacological considerations. The minority stress model is invoked throughout, with attention to multiply marginalized communities: those who are Two-Spirit, Black, Asian American, and Pacific Islander; those who are neurodivergent and disabled; and migrants, refugees, and unhoused people. Clinical discussions cover trauma-informed care; developmentally appropriate care across the lifespan; gender affirmation in the context of eating disorders, substance use disorders, pregnancy, and serious mental illness; care in the settings of incarceration and gender identity conversion efforts; systems-level change; collecting gender identity information in electronic health records; and building gender-affirming clinical environments"--